已知糖皮质激素是一些激素产生效应的必需条件。糖皮质激素的这种条件化作用称为“允许作用”(Permissive action),但糖皮质激素在中枢内对其他刺激效应是否也有增强作用尚未见报道。我们选用一种镇痛二肽(H-Arg-Jyr-OH)给大鼠作侧脑室注射,在观察其镇痛效应的同时,也观察该二肽与氢化可的松的缀合物N~2-(氢化可的松-21-O-丁二酰基)精-酪二肽(P.W.H_6II)对痛觉的影响,试图证明 Glucocorticoids are known to be essential for some hormone production effects. This conditioning of glucocorticoids is called a “permissive action,” but whether glucocorticoid has a potentiation of other stimulatory effects in the center has not been reported yet. We used an analgesic dipeptide (H-Arg-Jyr-OH) to rats for intracerebroventricular injection, observed its analgesic effect, but also observe the dipeptide and hydrocortisone conjugate N ~ Effect of 2- (hydrocortisone-21-O-succinyl) sperm-dipeptide (PWH_6II) on pain sensations in an attempt to demonstrate