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β -内酰胺类抗生素 (β -ｌａｃｔａｍｓ)是某些真菌 (如产黄青霉 )分泌的用来抵御细菌感染的次生代谢产物 ,它通过不可逆地抑制细胞壁合成和修复的有关酶类 ,来杀灭正在生长分裂的细菌细胞[1] 。自从Ｆｌｅｍｉｎｇ192 9年发现青霉素具有杀菌作用以来 ,β -内酰胺类抗生素仍
Beta-lactams are secondary metabolites secreted by certain fungi, such as P. chrysogenum, to fight bacterial infections by coming to irreversibly inhibit the enzymes involved in cell wall synthesis and repair Killing cells that are dividing and growing bacteria [1]. Since the discovery of penicillin as a bactericidal agent in Fleming’s 1992 study, beta-lactam antibiotics