论文部分内容阅读
糖尿病是以血糖浓度增高、胰岛素缺乏或作用下降为主要特征的慢性疾病,并能引起脂肪和蛋白质代谢紊乱。为了探索糖尿病的发病机理、血糖的调节机制以及评价等问题,建立能够模拟人类疾病特征的实验动物模型也备受关注。由于II型糖尿病或胰岛素抵抗与糖脂代谢密切相关,肥胖和高能量膳食摄入可增加其发病风险,所以高脂高糖膳食诱导肥胖型的糖尿病动物模型以及在此基础上联合小剂量链脲佐菌素(streptozocin,SZT)的造模方法被广泛应用。本文主要综述了II型糖尿病的机理,并就食物调节在糖尿病发病过程中的作用和影响,浅谈II型糖尿病的特点和制备过程中的的注意事项,以供参考。
Diabetes is a chronic disease characterized by increased blood glucose levels, lack of insulin or decreased function, and can cause disorders of fat and protein metabolism. In order to explore the pathogenesis of diabetes, the mechanism of glucose regulation and evaluation and other issues, to establish experimental animal models that can simulate the characteristics of human disease is also of concern. As type II diabetes or insulin resistance and glucose and lipid metabolism are closely related to obesity and high-energy dietary intake can increase the risk of its occurrence, so fat-induced hyperglycemia diet induced diabetic animal model of obesity and on this basis combined with low-dose streptozotocin Modeling methods of streptozocin (SZT) are widely used. This article mainly reviews the mechanism of type II diabetes and the role and influence of food regulation in the pathogenesis of diabetes. The characteristics of type II diabetes and the precautions in the preparation process are given for reference.