论文部分内容阅读
目的:探讨GST-π表达与乳腺癌生物学特性的关系.方法:利用GST-π抗体的免疫组化方法检测了38例乳腺癌和29例乳腺良性疾病患者组织GST-π的表达.结果:乳腺癌患者组织GST-π的阳性率为81.6%,明显高于乳腺良性肿瘤(41.4%)GST-π表达与乳腺癌患者的年龄、临床期别、肿瘤大小及有无淋巴结转移等无关,而与雌、孕激素受体状态呈负相关.结论:检测乳腺癌患者组织GST-π表达对乳腺癌的诊断和预后判断具有重要意义.
Objective: To investigate the relationship between expression of GST-π and biological characteristics of breast cancer. Methods: GST-π antibody immunohistochemistry was used to detect the expression of GST-π in 38 cases of breast cancer and 29 cases of benign breast disease. The positive rate of GST-π in breast cancer patients was 81.6%, which was significantly higher than that of benign breast tumors (41.4%). The expression of GST-π was not related to the age, clinical stage, tumor size and lymph node metastasis of breast cancer patients. Negative correlation was found between the estrogen and progesterone receptors. Conclusion: Detection of GST-π expression in breast cancer patients is of great significance in the diagnosis and prognosis of breast cancer.