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为了确定小剂量环孢素A(CSA)对系统性红斑狼疮(SLE)活动性的影响,作者对10例女性SLE患者在口服小剂量CSA共20周后,从临床及实验室资料观察了疾病活动性的变化。10例病人均符合美国风湿协会1982年修订的诊断标准,平均年龄为39.6±13.2岁;活动性指标至少有低补体血症,CH50≤20U/ml(正常为30～50);均无中枢神经系统(CNS)受损表现;无高血压;近三个月内未接受大剂量强的松龙或环磷酰胺的治疗。 病人开始口服CSA的剂量为3mg/kg/d,共20周。可根据CH50的水平作适量调整,如CH50仍低于正常值可加量,有肾脏受损可减
In order to determine the effect of low-dose cyclosporin A (CSA) on the activity of systemic lupus erythematosus (SLE), the authors observed the clinical and laboratory data of 10 women with SLE after oral administration of low-dose CSA for 20 weeks Changes in activity. All 10 patients met the diagnostic criteria revised by the American Rheumatism Association in 1982 with an average age of 39.6 ± 13.2 years. The activity index was at least as low as hypercholesterolemia, CH50 ≤ 20 U / ml (normal 30-50) System (CNS) impaired performance; no hypertension; no treatment with high-dose prednisolone or cyclophosphamide within the last three months. The patient started oral CSA dose of 3mg / kg / d, a total of 20 weeks. According to the level of CH50 for the right amount of adjustment, such as CH50 is still below the normal amount can be increased, with renal impairment can be reduced