未分化子宫内膜癌是一种侵袭性极强的高级别子宫内膜癌,被定义为一种由中等大小或大细胞构成的、完全缺乏腺样结构、缺乏或伴极少(<10%)神经内分泌分化的肿瘤,约占子宫内膜癌的9%。目前,由于病理医师对未分化子宫内膜癌的认识不足,使其经常不能被诊断,或者将其归入FIGO 3级子宫内膜样腺癌中。作者通过免疫组化等方法对未分化子宫内膜癌发展中的分子学水平变化进行研究,选取120例子宫内膜癌患者,其中Ⅰ+Ⅱ级的子宫内膜样腺癌57例,Ⅲ级子宫内膜样腺 Undifferentiated endometrial cancer is a highly aggressive, high-grade endometrial cancer defined as a medium-sized or large cell that is completely devoid of adenoid structures, lacking or companied with minimal (<10% ) Neuroendocrine differentiation of tumors, accounting for about 9% of endometrial cancer. Currently, pathologists often can not be diagnosed due to their poor understanding of undifferentiated endometrial cancer, or they are classified as FIGO grade 3 endometrioid adenocarcinomas. The authors studied the molecular changes in the development of undifferentiated endometrial carcinomas by immunohistochemistry and other methods. Totally 120 endometrial cancer patients were selected, including 57 cases of grade Ⅰ + Ⅱ endometrial adenocarcinoma, Ⅲ grade Endometrioid gland