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胃食管反流性疾病是胃、十二指肠的内容物自发性反流引起食管粘膜损伤,其发病与食道下端括约肌短暂和/或持久的松弛有关。其患病率在一定群体中随年龄而增加。临床表现多样且轻重不一。病史可提示诊断,但需做进一步检查。24小时食道内pH检查是诊断胃食管反流性疾病的最敏感的试验。治疗包括调整生活方式,无效后可根据症状和食管炎的严重程度决定选用抗酸剂、H_2受体阻滞剂、质子泵抑制剂等。严重的难治病例可外科手术。
Gastroesophageal reflux disease is a spontaneous reflux of the contents of the stomach and duodenum leading to esophageal mucosal injury whose onset is associated with transient and / or permanent relaxation of the lower esophageal sphincter. The prevalence in certain groups increased with age. Clinical manifestations vary in severity. Medical history can prompt diagnosis, but need further examination. The 24-hour esophageal pH test is the most sensitive test for the diagnosis of gastroesophageal reflux disease. Treatment, including the adjustment of lifestyle, invalid according to the severity of symptoms and esophagitis decided to use antacids, H_2 receptor blockers, proton pump inhibitors. Severe refractory cases can be surgical.