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目的探究胰岛素泵治疗儿童I型糖尿病合并酮症酸中毒的临床疗效及安全性。方法回顾性分析该院住院病房收治的62例I型糖尿病合并酮症酸中毒患儿临床资料,按照治疗方法不同分成两组,研究组实施胰岛素泵持续皮下泵入胰岛素治疗方法,对照组给予常规的皮下注射胰岛素治疗,评价治疗前后血糖情况、炎性因子、尿酮体转阴时间及不良反应发生情况。结果两组治疗前后血糖、血钾等指标比较差异无统计学意义(P>0.05)。研究组胰岛素治疗后酸中毒纠正时间、尿酮体转阴时间及平均住院时间均短于对照组,差异有统计学意义(P<0.05)。两组低血糖发生率比较差异有统计学意义(P<0.05)。结论胰岛素泵方式与皮下注射方式治疗儿童1型糖尿病合并酮症酸中毒总体疗效接近。相较于皮下注射,胰岛素皮下泵入方式见效更快,低血糖发生率低,建议临床推广。
Objective To investigate the clinical efficacy and safety of insulin pump in the treatment of children with type 1 diabetes and ketoacidosis. Methods The clinical data of 62 type I diabetic patients with ketoacidosis admitted to our hospital ward were retrospectively analyzed. According to the different treatment methods, the study group was divided into two groups. The study group received continuous subcutaneous insulin infusion with insulin pump and the control group received conventional Of subcutaneous insulin therapy, evaluation of blood glucose before and after treatment, inflammatory factors, urinary ketone body overcast time and adverse reactions. Results Before and after treatment, there were no significant differences in blood glucose, serum potassium and other indexes (P> 0.05). In the study group, the correct time of acidosis, the time of urine ketone body negative conversion and the average hospitalization time were shorter than the control group after insulin therapy, the difference was statistically significant (P <0.05). The incidence of hypoglycemia in the two groups was significantly different (P <0.05). Conclusion The overall efficacy of insulin pump and subcutaneous injection in treating children with type 1 diabetes and ketoacidosis is similar. Compared to subcutaneous injection, insulin subcutaneous pumping effect faster, low incidence of hypoglycemia, it is recommended clinical promotion.