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自1931年Von Euler和Gaddum从脑和肠组织的提取液中发现P物质以来,有关P物质体内的分布及其效应已有大量的工作,很多报导认为P物质对中枢神经系统活动有明显的影响而且与痛觉有关。在早期的工作一直认为P物质是一种强的致痛物质。
Von Euler and Gaddum, since their discovery of substance P in brain and intestine extracts in 1931, have done a great deal of work on the distribution and effect of substance P in vivo, and many reports suggest that substance P has a significant effect on central nervous system activity And pain-related. In the early days of work, substance P was believed to be a potent substance causing pain.