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锚蛋白(Ankyrins)是广泛分布于细胞膜上,由多个锚蛋白重复序列(ANK)结构域构成的连接蛋白。在多种可兴奋细胞,包括神经细胞、心肌细胞以及骨骼肌细胞中,Ankyrin-G不仅通过与细胞骨架蛋白和细胞黏附分子连接,参与细胞结构形成和分化,还能够直接与蛋白激酶和离子通道蛋白等胞膜蛋白连接,调节细胞内外离子交换以及电信号的生成和传导。Ankyrin-G表达异常有可能成为某些可兴奋细胞相关疾病发病机制的一部分。
Ankyrins are connexins that are widely distributed on the cell membrane and consist of multiple ankyrin repeat (ANK) domains. In a variety of excitable cells, including neurons, cardiomyocytes and skeletal muscle cells, Ankyrin-G not only through the cytoskeletal proteins and cell adhesion molecules connected to participate in the formation and differentiation of cell structure, but also directly with protein kinase and ion channels Protein and other membrane protein connections, regulate intracellular ion exchange and the generation and conduction of electrical signals. Ankyrin-G expression may be part of the pathogenesis of some excitable cell-related diseases.