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目的:探讨垂体后叶素、奥美拉唑联合生长抑素与垂体后叶素联合三腔两囊压迫止血治疗肝硬化并上消化道大出血的临床疗效及安全性。方法:收集58例于我院治疗的肝硬化并上消化道大出血患者。随机分为A组和B组,每组各29例。两组患者均给予保肝、输血、禁食、补充血容量。A组给予垂体后叶素50 U 0.1 u/min维持静滴,加用三腔两囊管压迫止血进行治疗;B组给予垂体后叶素50 U 0.1 u/min维持静滴,0.1~0.2 mg生长抑素加入20 m L生理盐水静脉缓慢推注,继以0.2 mg生长抑素以25~50μg/h静脉滴入,同时静脉滴注奥美拉唑40 mg,2次/日。治疗结束后,比较两组患者临床总有效率、不良反应发生率、止血时间及输血量。结果:与A组患者相比较,B组患者的临床总有效率、不良反应发生率、止血时间及输血量水平较低,差异具有统计学意义(P<0.05)。结论:垂体后叶素、奥美拉唑联合生长抑素治疗肝硬化并上消化道大出血患者比垂体后叶素联合三腔两囊压迫止血治疗的临床总有效率高,不良发应少,止血时间短,输血量少。
Objective: To investigate the clinical efficacy and safety of pituitrin, omeprazole combined with somatostatin and pituitrin combined with three-chamber two-capsule compression in the treatment of cirrhosis and upper gastrointestinal hemorrhage. Methods: We collected 58 cases of cirrhosis and upper gastrointestinal bleeding in our hospital. Randomly divided into A group and B group, each group of 29 cases. Two groups of patients were given liver protection, blood transfusion, fasting, blood volume. Group A was given pituitrin 50 U 0.1 u / min to maintain intravenous infusion plus three-chamber two cyst tube hemostasis for treatment; group B was given pituitrin 50 U 0.1 u / min to maintain intravenous infusion, 0.1 ~ 0.2 mg Somatostatin was injected slowly into the vein of 20 m L normal saline, followed by intravenous injection of 0.2 mg of somatostatin at 25 ~ 50 μg / h. Meanwhile, omeprazole 40 mg was intravenously dripped twice daily. After treatment, the total effective rate of the two groups, the incidence of adverse reactions, bleeding time and blood transfusion were compared. Results: Compared with group A, the total effective rate, the incidence of adverse reactions, the time to stop bleeding and the volume of blood transfusion in group B were significantly lower (P <0.05). Conclusion: Pituitrin, omeprazole combined with somatostatin in patients with cirrhosis and upper gastrointestinal bleeding than pituitary vasopressin combined with three-chamber two-capsule oppression hemostasis in the treatment of high total effective rate, fewer adverse reactions, hemostasis Short time, less blood transfusion.