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目的 :临床评价阿奇霉素粉针剂对呼吸道感染患者的疗效。方法 :16 0例我院呼吸科住院治疗的呼吸道感染患者 ,随机分成试验组和对照组。试验组用阿奇霉素粉针剂 2 5 0mg加入 2 5 0ml葡萄糖注射液静滴 ,qd ;对照组用红霉素粉针剂 1.0 g加入 10 0 0ml葡萄糖注射液静滴 ,qd ,疗程均为 5d ,观察用药前后患者临床表现变化及药物不良反应。观察两组药物对各种致病菌的清除率。结果 :试验组用药后临床症状明显改善 ,与对照组相比 ,疗效有显著差异 (P <0 .0 1)。试验组细菌清除率 81.5 8% ,对照组细菌清除率 30 .43% ,两组有显著性差异 (P <0 .0 1)。试验组不良反应少 ,总发生率 13.0 0 % ,而对照组不良反应总发生率 73.30 %。结论 :临床验证认为阿奇霉素粉针剂用于呼吸道感染的治疗是一种安全、有效的药物。
Objective: To evaluate the efficacy of azithromycin in patients with respiratory tract infections. Methods: One hundred and sixty patients with respiratory tract infection hospitalized in our hospital were randomly divided into test group and control group. The experimental group with azithromycin injection of 250mg intravenous infusion of 250ml glucose injection, qd; control group with erythromycin powder injection 1.0g intravenous infusion of 100ml glucose injection, qd, treatment were 5d, the observation medication Clinical manifestations of patients before and after changes and adverse drug reactions. The clearance rate of various pathogenic bacteria in two groups of drugs was observed. Results: The clinical symptoms of the experimental group improved significantly compared with the control group, there was significant difference (P <0.01). The bacterial clearance rate was 81.5% in the experimental group and 30.43% in the control group. There was significant difference between the two groups (P <0.01). The test group had fewer adverse reactions, with a total incidence of 13.0%, while the control group had a total incidence of adverse reactions of 73.30%. Conclusion: Clinical validation that azithromycin injection for the treatment of respiratory tract infection is a safe and effective drug.