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为验证高压氧的防治效果和进一步观察声暴露前预防给氧以及声暴露后治疗给氧的作用,设计了不同给氧时机防治豚鼠声损伤的实验方案。选择鼓膜正常,耳廓反应灵敏的豚鼠20只,分成四组,即声暴露对照组(简称对照组)高压氧预防组。(简称须防组),高压氧预防治疗组(简称防治组),高压氧治疗组(简称治疗组)。每组5只。另有5只正常动物作耳蜗制片对照用。每组动物均经1kHz,125dBSPL声场暴露3小时。高压氧防治各组接受2个绝对大气压高压氧处理30分钟(升压30分
In order to verify the effect of hyperbaric oxygen prevention and control and to further observe the effect of preventing oxygen supply before sonicate exposure and the treatment of oxygen after sonicate exposure, experimental schemes of preventing and treating guinea pig sonic damage with different timing of oxygen supply were designed. Twenty guinea pigs with normal tympanic membrane and sensitive auricle were selected and divided into four groups: hyperbaric oxygen group (control group). (Referred to as prevention group), hyperbaric oxygen prevention and treatment group (referred to as prevention and treatment group), hyperbaric oxygen therapy group (referred to as treatment group). 5 per group Another five normal animals for cochlear control purposes. Each group of animals were exposed to a sound field of 125 kHz for 3 hours at 1 kHz. Hyperbaric oxygen prevention and treatment groups received two absolute atmospheric hyperbaric oxygen treatments for 30 minutes (30 minutes of boost)