纤维结合素(*N)是主要由结缔组织细胞产生的高分子糖蛋白。它存在于细胞表面、结缔组织内和血浆中,具有多种生物活性。由于FN水平在不同疾病中的变动,引起了临床的重视。作者取特异性抗体用免疫浊度测定法,对血浆及关节液中的FN进行了测定。对象及方法抽取确诊的15例类风湿性关节炎(RA)患者、13例全身性红斑狼疮(SLE)患者及30例健康成人的用EDTA处理过的血浆。向15例RA及15例变形性膝关节症(OA)患者的加入过EDTA的关节液中,按每毫升关节液加入25单位的浓 Fibronectin (* N) is a high-molecular glycoprotein mainly produced by connective tissue cells. It exists in the cell surface, connective tissue and plasma, with a variety of biological activity. Due to the FN levels in different diseases, caused the clinical attention. Authors take specific antibodies by immunoturbidimetry, FN in plasma and synovial fluid were determined. Subjects and Methods Fifteen confirmed rheumatoid arthritis (RA) patients, 13 patients with systemic lupus erythematosus (SLE) and 30 healthy adults treated with EDTA were selected. To 15 RA and 15 patients with osteoarthritis (OA) of patients with EDTA-jointed joint fluid, per milliliter of joint fluid was added 25 units of concentrated