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Th17细胞是新近发现的一种CD4~+T细胞亚群,其主要产生的效应因子是IL-17。过去研究认为,Th1型的干扰素-γ和IL-12在组织炎性损伤中发挥重要作用。随着对Th17细胞的深入研究,发现其在介导慢性炎性反应和自身免疫性疾病发病机制中是关键的致病因素。本文简要对Th17细胞在炎性疾病中的促炎作用作一综述。
Th17 cells are a newly discovered subset of CD4 ~ + T cells whose main effector is IL-17. Past studies suggest that Th1-type interferon-γ and IL-12 play an important role in tissue inflammatory injury. With the further study of Th17 cells, it was found that it is the key causative factor in the pathogenesis of chronic inflammatory reaction and autoimmune diseases. This article briefly reviews the proinflammatory effects of Th17 cells in inflammatory diseases.