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目的:观察六味雪哈片对老年大鼠的抗衰老作用及机制研究。方法:15月龄大鼠40只均匀分为溶剂对照组、六味雪哈片低剂量组(0.36 g.kg-1)、中剂量组(0.72 g.kg-1)和高剂量组(1.44 g.kg-1)4组,连续ig 60 d后观察对动物体重增长、肝组织超氧化物岐化酶(SOD)活性、血清丙二醛(MDA)含量、血清谷胱甘肽过氧化物酶(GSH-Px)活性的影响。结果:六味雪哈片对动物体重增长和肝匀浆SOD活性无显著影响,但能显著降低血清MDA含量和提高血清GSH-Px活性。结论:六味雪哈片具有延缓衰老作用,其作用机制可能与其清除自由基、减少过氧化脂质的生成有关。
Objective: To observe the anti-aging effect and mechanism of Liuwei Xueha Tablet on aged rats. Methods: Forty-five-month-old rats were equally divided into solvent control group, low dosage of Liuwei Xueha tablets (0.36 g.kg-1), middle dosage of 0.72 g.kg-1 and high dosage of 1.44 g .kg-1) 4 groups, after continuous ig 60 days, the body weight gain, liver tissue superoxide dismutase (SOD) activity, serum malondialdehyde (MDA) content, serum glutathione peroxidase (GSH-Px) activity. RESULTS: Liuwei Xueha tablet had no significant effect on body weight gain and liver homogenate activity of SOD, but could significantly reduce serum MDA content and increase serum GSH-Px activity. CONCLUSION: Liuwei Xueha Tablet can delay aging and its mechanism may be related to its elimination of free radicals and reduction of lipid peroxidation.