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目的:探讨糖皮质激素联合环磷酰胺治疗肾病综合征的疗效及不良反应。方法:选取2015年6月-2016年6月在我院收治的94例肾病综合征患者,随机分为对照组与观察组,各组47例,观察组采用糖皮质激素与环磷酰胺联合治疗,对照组则单纯采用糖皮质激素实施治疗,观察比较两组治疗效果、并发症及治疗前后6个月各项指标。结果:两组白蛋白水平较之治疗前,均得到显著升高,血肌酐与24h尿蛋白量相比于治疗前,均明显降低(P<0.05);观察组上述指标均显著低于对照组,观察组缓解率(89.36%)较之对照组(70.21%),高于后者且差异显著(P<0.05),观察组不良反应发生率(38.30%)较之对照组(2.13%),高于后者(P<0.05)。结论:肾病综合征患者采用糖皮质激素与环磷酰胺联合治疗,效果显著,但具较多不良反应。
Objective: To investigate the efficacy and adverse reactions of glucocorticoid combined with cyclophosphamide in the treatment of nephrotic syndrome. Methods: Ninety-four patients with nephrotic syndrome admitted to our hospital from June 2015 to June 2016 were randomly divided into control group and observation group, with 47 cases in each group. The observation group was treated with glucocorticoid combined with cyclophosphamide , While the control group was treated with glucocorticoid alone. The therapeutic effect, complications and the indexes of 6 months before and after treatment were observed and compared. Results: Compared with before treatment, serum creatinine and serum creatinine in both groups were significantly higher than those before treatment (P <0.05). The above indexes in the observation group were significantly lower than those in the control group (89.36%) in the observation group was higher than that of the control group (70.21%), and the difference was significant (P <0.05). The incidence of adverse reactions in the observation group (38.30%) was significantly higher than that of the control group Higher than the latter (P <0.05). Conclusion: Nephrotic syndrome patients treated with glucocorticoid and cyclophosphamide, the effect is significant, but with more adverse reactions.