论文部分内容阅读
目的 :探讨干扰素抗体 (抗 IFN)对干扰素 (IFN)治疗肝炎疗效的影响。方法 :用间接酶联免疫吸附法 ,检测 72例接受不同种类α干扰素治疗的慢性病毒性肝炎患者的血清抗 IFN。结果 :9 72 %的患者在IFN治疗前已有抗 IFN存在。随着IFN使用时间的延长 ,抗 IFN阳性率逐渐上升 ,至治疗结束时为 3 8 89% ,随访期为 4 4 4 4% ,明显高于治疗前 (P <0 0 1)。治疗结束时 ,完全应答者 2 5例中仅 5例 ( 2 0 % )抗 IFN阳性 ,而部分应答及无应答者分别为 9例 ( 5 0 % )和 14例 ( 4 8 2 8% ) ,差异显著 (P <0 0 5 )。随访结果显示 ,抗 IFN阳性者复发率略高于阴性者。结论 :抗 IFN可影响IFN的疗效 ,抗 IFN阴性者的疗效明显优于抗 IFN阳性者。治疗前及疗程中监测抗 IFN ,对提高IFN的疗效有一定价值。
Objective: To investigate the effect of interferon (IFN) on the efficacy of interferon (IFN) in the treatment of hepatitis. Methods: Serum anti-IFN was measured in 72 patients with chronic viral hepatitis treated with different kinds of interferon-alpha by indirect enzyme-linked immunosorbent assay. Results: Ninety-two percent of patients already had anti-IFN prior to IFN treatment. With the prolongation of the use of IFN, the positive rate of anti-IFN gradually rose to 38.89% at the end of treatment and 44.4% at follow-up, which was significantly higher than that before treatment (P <0.01). At the end of treatment, only 5 (20%) of 25 complete responders had anti-IFN positive, while 9 (50%) and 14 (488%) had partial or no response, respectively, The difference was significant (P <0 05). The follow-up results showed that the relapse rate of anti-IFN positive patients was slightly higher than that of negative ones. Conclusion: Anti-IFN can affect the efficacy of IFN, anti-IFN-negative patients were significantly better than anti-IFN-positive. Pretreatment and monitoring of anti-IFN during treatment, to improve the efficacy of IFN has a certain value.