论文部分内容阅读
可的松、氫化可的松、强的松及强的松龙等药物不仅对肉芽肿組織的生长有明显抑制作用,而且能降低肉芽肿組織內維生素C含量。其他抗炎药物如ACTH及水楊酸鈉对肉芽肿生长无抑制作用,但能使其中維生素C含量降低;甘草次酸能抑制肉芽肿的生长,却不能使維生素C含量降低。可的松对非結締組織性生长——肉瘤-180有明显抑制作用,唯对瘤組織內維生素C含量并无影响。对大鼠血、肝、脾、腎及心等脏器内維生素C含量亦无作用。不同剂量的强的松龙能引起肉芽肿重量及其中維生素C含量不同程度的降低,但在肉芽肿的重量已开始明显减輕时,維生素C含量的降低尚不明显。当大鼠皮下埋棉球后第四天开始注射可的松,肉芽肿重量不受抑制,但其中維生素C含量却有明显降低。此外,可的松对肉芽肿生长的抑制作用不能为同时給于維生素C所对抗。以上結果表明,糖皮质激素等药物在抑制肉芽組織的生长时,虽能引起該组織內維生素C含量明显降低。但是,腎上腺皮质激素的抗炎作用并不通过对維生素C的影响而实現。
Cortisone, hydrocortisone, prednisone and prednisolone and other drugs not only significantly inhibited the growth of granuloma tissue, but also reduce the content of vitamin C in granuloma tissue. Other anti-inflammatory drugs such as ACTH and sodium salicylate did not inhibit the growth of granulomas, but decreased vitamin C levels. Glycyrrhetinic acid inhibited granuloma growth but did not reduce vitamin C content. Cortisone on non-connective tissue growth - sarcoma -180 significant inhibitory effect, only the content of vitamin C in the tumor tissue had no effect. On rat blood, liver, spleen, kidney and heart and other organs also had no effect on vitamin C content. Different doses of prednisolone can cause granuloma weight and vitamin C content in varying degrees of reduction, but when the weight of granulomas has begun to significantly reduce, the reduction of vitamin C content is not obvious. When cortisone was injected on the fourth day after the rat subcutaneously buried the cotton ball, the weight of the granuloma was not inhibited, but the content of vitamin C was significantly decreased. In addition, cortisone on granuloma growth inhibition can not be given at the same time against the vitamin C confrontation. The above results show that glucocorticoids and other drugs in the inhibition of granulation tissue growth, although it can cause a significant reduction in vitamin C content in the tissue. However, the anti-inflammatory effect of adrenal cortical hormone is not achieved through the impact of vitamin C.