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进行盐酸菲洛普（Ｐｈｅｎｏｐｒｏｌａｍｉｎｅ，ＰＨＥＮＯＰ）对大鼠膀胱内压及前列腺增生的药效学研究。结果发现，在离体兔膀胱颈平滑肌，苯肾上腺素（Ｐｈｅ）能增加平滑肌收缩力，ＰＨＥＮＯＰ能浓度依赖性地使Ｐｈｅ的量效曲线平行右移，且最大反应不变（ｐＡ２＝７．２４）；ＰＨＥＮＯＰ２５．０、５０．０ｍｇ／ｋｇ灌胃能改变正常麻醉大鼠膀胱内压图，使膀胱容积、排尿压、排尿阈值压显著降低；在用丙酸睾丸素引起大鼠前列腺增生的实验中，ＰＨＥＮＯＰ１２．５、２５．０及５０．０ｍｇ／ｋｇ灌胃４周还可抑制大鼠前列腺组织的增生。提示，ＰＨＥＮＯＰ作为抗前列腺增生药及改善尿流率的药物可能有应用前景
Pharmacodynamic study of Phenoprolamine (PHENOP) on intravesical pressure and benign prostatic hyperplasia in rats. The results showed that in isolated rabbit bladder neck smooth muscle, phenylephrine (Phe) increased smooth muscle contractility, PHENOP dose-response curve in a concentration-dependent parallel shift to the right, and the maximum response unchanged (pA2 = 7.24 ); PHENOP25.0, 50.0mg / kg gavage can change the normal anesthetized rat bladder pressure map, the bladder volume, voiding pressure, micturition threshold pressure was significantly reduced; testosterone propionate in rats caused by benign prostatic hyperplasia , PHENOP12.5,25.0 and 50.0mg / kg gavage for 4 weeks can inhibit the proliferation of rat prostate tissue. Tip, PHENOP as anti-benign prostatic hyperplasia medicine and improve the flow rate of the drug may have application prospects