【摘 要】
：
Prognostication of coma patients after brain injury is important,yet challenging.In this study,we evaluated the predictive value of amplitude-integrated electroencephalography (aEEG) for neurological outcomes in coma patients.From January 2013 to January
【机 构】
：
Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shan
论文部分内容阅读
Prognostication of coma patients after brain injury is important,yet challenging.In this study,we evaluated the predictive value of amplitude-integrated electroencephalography (aEEG) for neurological outcomes in coma patients.From January 2013 to January 2016,128 coma patients after acute brain injury were prospectively enrolled and monitored with aEEG.The 6-month neurological outcome was evaluated using the Cerebral Performance Category Scale.aEEG monitoring commenced at a median of 7.5 days after coma onset.Continuous normal voltage predicted a good 6-month neurological outcome with a sensitivity of 93.6％ and specificity of 85.2％.In contrast,continuous extremely low voltage,burst-suppression,or a flat tracing was correlated with poor 6-month neurological outcome with a sensitivity of 76.5％ and specificity of 100％.In conclusion,aEEG is a promising predictor of 6-month neurological outcome for coma patients after acute brain injury.
其他文献
Dear Editor,rnBody protection compound (BPC) 157 is a stable gastric pentadecapeptide.Predrag Sikiric\'s team has carried out many investigations of its cytoprotective effects in different organs and tissues [1,2].Their evidence indicates that BPC157 ha
Treatment for disorders of consciousness (DOCs) is still a Gordian knot.Evidence-based guidelines on the treatment of DOC patients are not currently available,while neuromodulation techniques are seen as a potential treatment.Multiple neuromodulation ther
In this study,we developed a systemic PD model in middle-aged cynomolgus monkeys using individualized low-dose MPTP,to explore effective indicators for the early prediction of clinical outcomes.MPTP was not stopped until the animals showed typical PD moto
Orthostatic intolerance (OI) is a series of clinical symptoms that develop during long-term standing in the upright position,with clinical manifestations of frequent,recurrent,or persistent dizziness,fatigue,and heart palpitations with or without syncope.
Exposure therapy,an effective treatment for fear disorders,requires memory retrieval of previous horror experiences in controllable environment.However,it remains unknown whether previous fear memories have been updated [1] or inhibited [2] during the for
Mental disorder is defined as a syndrome characterized by clinically significant disturbance in an individual\'s cognition,emotion,or behavior that reflects a dysfunction in the psychological,biological,or developmental processes underlying mental funct
Investigating the pathophysiological mechanisms underlying brain disorders is a priority if novel therapeutic strategies are to be developed.In vivo studies of animal models and in vitro studies of cell lines/primary cell cultures may provide useful tools
Previous genetic fate-mapping studies have indicated that embryonic glial fibrillary acidic proteinpositive (GFAP+) cells are multifunctional progenitor/neural stem cells that can produce astrocytes as well as neurons and oligodendrocytes throughout the a
Cyproheptadine (CPH),a first-generation antihistamine,enhances the delayed rectifier outward K+ current (IK) in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway.In this study,we aimed to determine the effects of CPH on n
Neuroplastin 65 (Np65) is an immunoglobulin superfamily cell adhesion molecule involved in synaptic formation and plasticity.Our recent study showed that Np65-knockout (KO) mice exhibit abnormal cognition and emotional disorders.However,the underlying mec