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目的分析亚胺培南/西司他丁用于抗感染治疗时对肾脏功能的影响。方法对严重肺部感染患者45例进行回顾性分析,按照使用亚胺培南/西司他丁时间的长短不同分为A、B、C 3组。结果治疗后,所有患者血尿素氮(BUN)和肌酐(CRE)、尿白蛋白(U-ALB)和β2微球蛋白定量(Uβ2-MG)均有所下降(P<0.01),其中U-ALB和Uβ2-MG仍高于正常,但这种变化组间比较差异均无统计学意义(P>0.05)。结论亚胺培南/西司他丁用于治疗严重感染时,不影响患者肾功的恢复。
Objective To analyze the effect of imipenem / cilastatin on renal function in anti-infective therapy. Methods A total of 45 patients with severe pulmonary infection were retrospectively analyzed. Groups A, B and C were divided according to the duration of imipenem / cilastatin. Results After treatment, the blood urea nitrogen (BUN), creatinine (CRE), urinary albumin (U-ALB) and β2 microglobulin (Uβ2-MG) were decreased in all patients (P <0.01) ALB and Uβ2-MG were still higher than normal, but there was no significant difference between the two groups (P> 0.05). Conclusion Imipenem / cilastatin can not affect the recovery of renal function in patients with severe infections.