【摘 要】
：
目的 对牛痘疫苗接种家兔炎症皮肤提取物(神经妥乐平)治疗2型糖尿病(type 2 diabetes)同时合并周围神经病变(DPN)病人的作用效果和药物使用的安全性进行系统评价,为神经妥乐平在2型糖尿病病人同时合并DPN治疗中的合理使用提供循证证据.方法 检索循证图书馆、PubMed文献数据库、EMBASE、万方电子数据库、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)等,按照筛选标准对神经妥乐平治疗DPN相关的临床随机对照研究(RCT)相关文章进行收集整理,检索时限从各数据库建库起至20
【机 构】
：
天津市胸科医院药剂科,天津 300222
论文部分内容阅读
目的 对牛痘疫苗接种家兔炎症皮肤提取物(神经妥乐平)治疗2型糖尿病(type 2 diabetes)同时合并周围神经病变(DPN)病人的作用效果和药物使用的安全性进行系统评价,为神经妥乐平在2型糖尿病病人同时合并DPN治疗中的合理使用提供循证证据.方法 检索循证图书馆、PubMed文献数据库、EMBASE、万方电子数据库、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)等,按照筛选标准对神经妥乐平治疗DPN相关的临床随机对照研究(RCT)相关文章进行收集整理,检索时限从各数据库建库起至2019年12月.先对纳入研究做临床证据质量评价,再进一步运行RevMan(版本5.3)对各指标数据(总有效率、正中神经运动神经传导速度、胫神经运动神经传导速度以及不良反应发生率)进行分析.结果 共纳入9篇文献,总计934例病人.研究最终结果表明,在DPN的药物治疗效果方面,试验组药物治疗总有效率较对照组具有更多优势[OR=3.91,95％CI(2.64～5.78),P<0.001].在改善神经功能障碍方面,试验组的正中神经[MD=4.07 m/s,95％CI(2.12～6.03),P<0.001]以及胫神经的运动神经传导速度[MD=2.93 m/s,95％CI(2.08～3.79),P<0.001]也较对照组显著提高.在药品的安全性方面,试验组神经妥乐平的药品不良反应(ADR)发生率与对照组差异无统计学意义.结论 神经妥乐平作为一种有效性较好的临床药物,可显著改善神经功能,具有广泛的临床应用价值,同时对于其发生不良反应的风险在临床使用中仍需予以重视.
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