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本文应用抗ＨＬＡ－Ⅰ类重链单态决定簇和抗免疫抑制酸性蛋白Ⅱ型（ＩＡＰ－２）单克隆抗体，分别对６４例胃癌、癌旁组织和６例正常胃粘膜冰冻和石蜡切片进行了免疫组化分析。结果表明，正常胃粘膜及癌旁上皮细胞ＩＡＰ－２表达阴性，ＨＬＡ－Ⅰ类分子表达阳性。但在胃癌组织Ⅰ类分子表达缺失（４２．２％），ＩＡＰ－２表达阳性（９０．５％）。其中肿瘤分化程度与Ⅰ类分子缺失和ＩＡＰ－２高表达均呈负相关，即分化程度越低，Ⅰ类分子缺失率越高，ＩＡＰ－２表达阳性率亦越高。提示：①ＨＬＡ－Ⅰ类分子表达缺失可能是胃癌细胞逃避宿主免疫监视而得以生长、扩散和转移的机理之一；②ＩＡＰ－２的高表达可能是胃癌细胞引起宿主免疫抑制的重要因素。
In this study, anti-HLA class I heavy chain singlet determinants and anti-immunosuppressive acidic protein type II (IAP-2) monoclonal antibodies were applied to 64 cases of gastric cancer, paracancerous tissues, and 6 normal gastric mucosa frozen and paraffin sections. Immunohistochemical analysis. The results showed that IAP-2 was negative in normal gastric mucosa and paracancerous epithelial cells, and HLA-I molecules were positive. However, in patients with gastric cancer, the expression of type I molecules was missing (42.2%), and IAP-2 expression was positive (90.5%). The degree of tumor differentiation was negatively correlated with the loss of type I molecules and high expression of IAP-2. The lower the degree of differentiation, the higher the rate of deletion of type I molecules and the higher the positive rate of IAP-2 expression. It is suggested that the lack of HLA-I expression may be one of the mechanisms by which gastric cancer cells can evade host immune surveillance to grow, spread, and metastasize.2 The high expression of IAP-2 may be an important factor in the host immune suppression caused by gastric cancer cells.