【摘 要】
：
Twenty-one lignans including three new ones (1,2 and 13) were isolated from Justicia procumbens.The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis.These compounds were evaluated for their cyt
【机 构】
：
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China;Institute of Marine D
论文部分内容阅读
Twenty-one lignans including three new ones (1,2 and 13) were isolated from Justicia procumbens.The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis.These compounds were evaluated for their cytotoxic and anti-HIV activities.The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·L-1 and a selective index (SI) value of 2.2.The known arylnaphthalene lignan procumbenoside A (3) and diphyllin (8) demonstrated inhibitory activity against HIV-1 with IC50values of 4.95 (SI ＞ 6.2) and 0.38 μmol·L-1 (SI =5.3),respectively.
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