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用去氧胆酸钠对水溶性差的、具有较大接触角的保泰松(109°)和消炎痛(90°)分别应用吸附法和混合法制成保泰松和消炎痛混合物,以提高它们的溶出速率。吸附法:精密称取保泰松和消炎痛药粉0.5g,分别置20ml 玻瓶中,加入5ml0.05%(W/V)和0.1%(W/V)胆盐水溶液,置水浴中恒温(37°)振摇1小时,于3°冰箱中放置过夜,过滤,真空干燥后即得。保泰松加入0.05%(W/V)和0.1%(W/V)的胆盐分别吸附1.9mg 和3.5mg,消炎痛吸附胆盐量仅为1.5mg。
Pseudo pine (109 °) and indomethacin (90 °), which are poorly water-soluble and have a large contact angle, were treated with sodium deoxycholate to prepare mixtures of phenylbutazone and indomethacin by adsorption and mixing, respectively, to increase their Dissolution rate. Adsorption method: accurately weighed Phenylbutazone and indomethacin powder 0.5g, respectively, set 20ml glass bottle, add 5ml0.05% (w / v) and 0.1% (w / v) bile saline solution, set the water bath temperature °) shaken for 1 hour, placed in a refrigerator at 3 ° overnight, filtered and dried in vacuo. Phenylbutazone with bile salts of 0.05% (W / V) and 0.1% (W / V) adsorbed 1.9 mg and 3.5 mg, respectively, and indomethacin absorbed bile salts only 1.5 mg.