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五十年代国内曾有人报道,葛根有降血糖作用。近年来,随着对葛根研究的深入,已证明异黄酮化合物葛根素(puerarin)是葛根的主要有效成分,有扩张血管、改善心肌代谢、降低高血压病人的血浆儿茶酚胺含量和抑制血小板聚集等作用。阿斯匹林也有多方面的药理作用,特别是能抑制前列腺素的合成、增加葡萄糖引起的胰岛素分泌、降血糖、降血脂,并能加强第二代口服降血糖药glipizide的降血糖作用。为了寻找既降血糖又能防治糖尿病心血管并发症的药物或复方,我们选用葛根素与小剂量阿斯匹林复方,对其降血糖、降血脂等作用进行了初步研究。
In the 1950s, some people in China reported that Pueraria has hypoglycemic effect. In recent years, with the further research on Puerariae, puerarin has been proved to be the main active ingredient of Pueraria lobata, which has the functions of dilating blood vessels, improving myocardial metabolism, reducing plasma catecholamine levels and inhibiting platelet aggregation in hypertensive patients . Aspirin also has a variety of pharmacological effects, in particular, can inhibit prostaglandin synthesis, increased glucose-induced insulin secretion, hypoglycemia, hypolipidemic, and can enhance the second generation of oral hypoglycemic agents glipizide hypoglycemic effect. In order to find a drug or compound that can both lower blood sugar and prevent cardiovascular complications of diabetes, we used puerarin and low-dose aspirin compound to study its hypoglycemic and hypolipidemic effect.