目的　探讨胎盘滋养细胞E 钙黏附素 (E Cadherin)的异常表达在妊娠期高血压疾病发病中的作用。方法　收集 2 0 0 0年 7月至 2 0 0 1年 11月新疆医科大学附一院 4 0例妊娠期高血压疾病 (研究组 )和 4 3例正常妊娠孕妇 (对照组 )的胎盘组织 ,采用免疫组化法测定两组胎盘组织E 钙黏附素的表达 ,分析其表达异同。结果　研究组胎盘E 钙黏附素的表达明显高于对照组 ,差异有显著性 (P <0 0 1)。结论　 (1)胎盘组织E 钙黏附素的异常表达导致胎盘浅着床 ,可能是妊娠期高血压疾病发病的始发原因之一。 (2 )E 钙黏附素的异常表达与妊娠期高血压疾病不良妊娠结局有关。 Objective To investigate the role of abnormal expression of placental trophoblast E Cadherin in the pathogenesis of hypertensive disorder complicating pregnancy. Methods Totally 40 cases of pregnancy-induced hypertension (study group) and 43 normal pregnant women (control group) were collected from the Affiliated Hospital of Xinjiang Medical University from July 2000 to November 2011. Placenta tissue, The expression of E-cadherin in placenta of two groups was detected by immunohistochemistry, and their similarities and differences were analyzed. Results The placental E-cadherin expression was significantly higher in the study group than in the control group (P <0.01). Conclusion (1) The abnormal expression of E-cadherin in placenta leads to the shallow placenta implantation, which may be one of the reasons of the onset of hypertensive disorder complicating pregnancy. (2) The abnormal expression of E-cadherin is associated with adverse pregnancy outcomes in hypertensive disorder complicating pregnancy.