1981～1984年在四季青乡检测孕妇血清甲胎蛋白以筛选开放性神经管缺损畸形2,812名,随访2,798名,畸形发生率为13.58‰(38/2,798),神经管缺损畸形发生率7.50‰(21/2,798),占全部畸形的55.26%。在孕28周前检出的畸形均给以终止妊娠,使该乡的围产死亡率从28.23‰降至22.15‰。研究证明在乡一级以孕妇血清甲胎蛋白筛选开放性神经管缺损畸形对降低围产死亡率有重要意义。 A total of 2,812 open neural tube defects were screened from 1981 to 1984 in Aizhixingqing for 2,798 malformations. The incidence of deformity was 13.58 ‰ (38 / 2,798), and the incidence of neural tube defects was 7.50 ‰ ( 21 / 2,798), accounting for 55.26% of all deformities. Twenty-eight weeks before the pregnancy was detected abnormalities were given to terminate the pregnancy, so that the perinatal mortality rate dropped from 28.23 ‰ to 22.15 ‰. Studies have shown that at the township level to pregnant women serum alpha-fetoprotein screening of open neural tube defects to reduce perinatal mortality is of great significance.