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脱氧三尖杉酯碱Ⅰ。对动物肿瘤P-388有明显的抑制作用。本文报道了三尖杉碱的十二个新的酯类化合物的合成及其抗肿瘤作用。药理实验发现合成的脱氧三尖杉酯碱(差向异构物混合体)有一定的抗肿瘤作用。通过化学结构和抗肿瘤活性的比较,初步推断酯碱Ⅰ.侧链的异丙基和α-叔羟基及甲氧羰甲基是抗肿瘤所必需的结构。
Dextrin harringtonine Ⅰ. Animal tumor P-388 has a significant inhibitory effect. This article reports the synthesis and antitumor effects of twelve new ester compounds of poinlline. Pharmacological experiments found that the synthesis of deoxyharringtonine (epimeric mixture) have a certain anti-tumor effect. Through chemical structure and antitumor activity comparison, it is concluded that the ester-base Ⅰ. Isopropyl and α-tert-hydroxy and methylcarbomethoxy in the side chain are the necessary anti-tumor structures.