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目的：采用相对定量分析法评估９９ｍＴｃ－ＥＣＤ脑血流灌注显像对小儿原发性癫痫定性和病灶定位的诊断价值。方法：２１例ＣＴ检查正常的小儿原发性癫痫病人进行９９ｍＴｃ－ＥＣＤ脑显像和相对定量分析，并同步进行ＥＥＧ检查。结果：２１例病人ＳＰＥＣＴ显像１８例异常，３例正常，阳性率８５７％，假阴性１０％，１８例脑显像异常患儿中，１６例局部脑血流（ｒＣＢＦ）减少，９９ｍＴｃ－ＥＣＤ摄取率７２６±８９％，２例在额叶有限局性ｒＣＢＦ增加，９９ｍＴｃ－ＥＣＤ摄取率分别为１４９５％和１３０９％。ＥＥＧ检查２１例病人２０例异常，１例正常，阳性率９５２％，能定位诊断的７例，定位率为３５％。结论：９９ｍＴｃ－ＥＣＤ脑显像相对定量分析法对小儿原发性癫痫病灶的定位有临床意义，优于ＥＥＧ。
OBJECTIVE: To evaluate the diagnostic value of 99mTc-ECD cerebral perfusion imaging in qualitative and focal localization of children with primary epilepsy using relative quantitative analysis. Methods: Twenty-one cases of primary epilepsy in children with normal CT were enrolled in the 99mTc-ECD brain imaging and relative quantitative analysis, and EEG examination was performed simultaneously. Results: Among the 21 patients, 18 cases were abnormal in SPECT imaging, 3 cases were normal, the positive rate was 85.7%, the false negative rate was 10%. Among 18 children with abnormal brain imaging, 16 had decreased cerebral blood flow (rCBF) and 99mTc -ECD uptake was 72.6 ± 89%. Two cases had increased rCBF in the frontal lobe and the uptake rates of 99mTc-ECD were 1495% and 1309% respectively. 21 cases of EEG examination of 20 patients with abnormal, 1 case of normal, the positive rate of 95 2%, can locate the diagnosis of 7 cases, the positioning rate was 35%. Conclusion: Relative quantification of 99mTc-ECD brain imaging has clinical significance in the localization of primary epilepsy in children, which is superior to EEG.