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目的探讨胃肠道间质瘤(GIST)的临床流行病学特征。方法应用临床流行病学研究方法,调查、分析山西省2000年至2005年GIST的临床流行病学特点。结果山西省2000年1月至2005年12月共发现GIST181例,每年临床上新发病例数都在增加,患者均为汉族。性别间差异无统计学意义。发病年龄16￣80岁,中位年龄57岁,发病随年龄增加而增高。太原、长治和晋中三地发病例数较多。城镇患者多见。GIST可发生在消化道任何部位,好发部位依次为胃、小肠、结直肠和食管,发生在胃肠道的占76.83%,胃肠道外的占23.17%。常见症状与体征有吞咽困难、恶心、呕吐、腹痛、腹胀、腹部肿块和消瘦。组织学形态:梭形细胞型占70.30%,上皮细胞型占12.10%,混合细胞型占17.60%。核分裂象≤5个/50HPF,占49.50%,6￣10个/50HPF,占36.30%,≥10个/50HPF,占14.30%。免疫表达情况:表达CD117占80.20%,CD34占67.00%,MCK无阳性表达。结论GIST是一种少见的肿瘤,在人群中散在分布。GIST可发生在消化道任何部位,好发部位依次为胃、小肠、结直肠和食管。GIST的临床发病呈逐渐增多趋势。
Objective To investigate the clinical epidemiological features of gastrointestinal stromal tumors (GIST). Methods Clinical epidemiological methods were used to investigate and analyze the clinical epidemiological characteristics of GIST from 2000 to 2005 in Shanxi Province. Results A total of 181 cases of GIST were found in Shanxi Province between January 2000 and December 2005, and the number of newly diagnosed cases was increasing every year. All patients were Han nationality. Gender differences were not statistically significant. The age of onset of 16 to 80 years old, the median age of 57 years old, the incidence increased with age. Taiyuan, Changzhi and Jinzhong three cases of more cases. More common in urban patients. GIST can occur in any part of the digestive tract, the predilection sites were stomach, small intestine, colorectal and esophagus, accounting for 76.83% of the gastrointestinal tract, gastrointestinal tract accounted for 23.17%. Common symptoms and signs of dysphagia, nausea, vomiting, abdominal pain, abdominal distension, abdominal mass and weight loss. Histological morphology: spindle cell type accounted for 70.30%, epithelial cell type accounted for 12.10%, mixed cell type accounted for 17.60%. Mitotic images ≤ 5 / 50HPF, accounting for 49.50%, 6 ~ 10 / 50HPF, accounting for 36.30%, ≥ 10 / 50HPF, accounting for 14.30%. Immune expression: expression of CD117 accounted for 80.20%, CD34 accounted for 67.00%, MCK no positive expression. Conclusions GIST is a rare tumor that is scattered throughout the population. GIST can occur in any part of the digestive tract, predilection sites were stomach, small intestine, colorectal and esophagus. The clinical incidence of GIST is gradually increasing.