论文部分内容阅读
贲门失弛缓症的临床表现为食管通过障碍及并发的夜间咳嗽、呕吐、前胸部痛、体重减轻等。治疗手段主要是外科手术。目前用钙拮抗剂治疗食管失弛缓症的临床应用研究发展迅速。本文作者研究了硝苯啶、异搏定、硫氮(艹卓)酮三种钙拮抗剂对犬的食管下端括约压的作用,结果不仅对静止压,而且对由胃泌素样肽或氨甲酸甲胆碱引起的括约压的升高也产生抑制作用。给犬硝苯啶0.5mg/kg舌下含化后,很快出现了括约压降低,约30分钟达最低值。30分钟乃至1～2小时仍有持续效果。硝苯啶对健康人也可产生剂量依赖性食管下端括
Cardiac achalasia clinical manifestations of esophageal obstruction and concurrent night cough, vomiting, chest pain, weight loss and so on. The main treatment is surgery. Currently, the clinical application of calcium antagonists in the treatment of esophageal achalasia is developing rapidly. The authors studied the effect of three calcium antagonists, nifedipine, verapamil, and thiadiazole, on the lower esophageal contractile pressure in dogs, not only for resting pressure but also for gastrin-like peptides or Increased caicidal pressure due to carbamate carbamate also produces an inhibitory effect. To dog nifedipine 0.5mg / kg sublingual, soon appeared to reduce the contract pressure, about the lowest value of 30 minutes. 30 minutes or even 1 to 2 hours still lasting effect. Nifedipine can also produce dose-dependent lower esophageal endpoints in healthy people