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目的：探讨综合干预对恢复期急性一氧化碳中毒后迟发性脑病患者生活质量的影响。方法将80例恢复期急性一氧化碳中毒后迟发性脑病患者随机分为两组，每组40例，两组均给予常规药物治疗及护理，研究组在此基础上联合心理治疗及康复训练。观察8周。于治疗前后采用日常生活能力量表和生活质量综合评定量表评定日常生活能力及生活质量。结果治疗8周末两组日常生活能力量表评分均较治疗前显著降低（P＜0．01），研究组显著低于对照组（P＜0．01）；两组生活质量综合评定量表总分及躯体健康、心理健康、社会功能维度分均较治疗前显著升高（P＜0．05或0．01），且研究组显著高于对照组（P＜0．05）。结论综合干预能显著提高恢复期急性一氧化碳中毒后迟发性脑病患者的日常生活能力和生活质量。“,”Objective To expore the influence of comprehensive intervention on the quality of life of pa-tients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) .Methods Eighty convalescence DEACMP patients were randomly divided into two groups of 40 ones each ,both groups re-ceived routine medication and nursing ,and on this basis research group was plus comprehensive interven-tion and rehabilitation training for 8 weeks .Activities of daily living were assessed with the Activity of Daily Living Scale (ADL) and qualities with the Generic Quality of Life Inventory-74 (GQOLI-74) before and after treatment .Results At the end of the 8th week the ADL scores of both groups lowered more sig-nificantly compared with pretreatment (P< 0 .01) ,that was significantly lower in research than control group (P<0 .01);the GQOLI total ,physical and mental health and social function score heightened more significantly after treatment compared with pretreatment (P< 0 .05 or 0 .01) ,those were significantly higher in research than control group (P<0 .05) .Conclusion Comprehensive intervention could improve activities of daily living and quality of life of DEACM P patients .