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目的:探讨姜黄素对癫痫大鼠认知功能障碍的预防作用及机制。方法:选取45只癫痫大鼠随机分为姜黄素干预组(n=15)、单纯致痫组(n=15)和正常对照组(n=15),检测其学习记忆功能情况以及超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)和丙二醛(MDA)水平。结果:单纯致痫组大鼠寻找平台潜伏期长于正常对照组(P<0.05);姜黄素干预组大鼠寻找平台潜伏期短于单纯致痫组(P<0.05)。单纯致痫组大鼠脑组织的SOD、GSH、GSH-Px水平低于正常对照组(P<0.05),而MDA水平明显较高(P<0.05);姜黄素干预组大鼠脑组织的SOD、GSH、GSH-Px水平高于单纯致痫组(P<0.05);不同浓度姜黄素干预组大鼠在寻找平台潜伏期以及各项指标水平组间比较,差异无统计学意义(P>0.05)。结论:姜黄素能够明显减轻癫痫状态下的大鼠认知功能障碍。
Objective: To investigate the preventive effect and mechanism of curcumin on cognitive dysfunction in epileptic rats. Methods: Forty-five epilepsy rats were randomly divided into curcumin intervention group (n = 15), epilepsy group (n = 15) and normal control group (n = 15), and their learning and memory function and superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels. Results: The incubation period of platform in epilepsy group was longer than that in normal control group (P <0.05). The incubation period of platform in curcumin intervention group was shorter than that in epilepsy group (P <0.05). The levels of SOD, GSH and GSH-Px in brain of rats with epilepsy were lower than those of normal control (P <0.05), while the levels of MDA were significantly higher in the epileptic rats (P <0.05) (P <0.05). The levels of GSH and GSH-Px in epilepsy group were significantly higher than those in epilepsy group (P <0.05). There was no significant difference between the two groups in the concentration of different concentrations of curcumin (P> 0.05) . Conclusion: Curcumin can significantly reduce cognitive impairment in rats with epilepsy.