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目的探讨慢性丙型肝炎肝硬化患者ALT、AST与GGT血清肝纤维化标志物透明质酸(HA)、层粘连蛋白(LN)、Ⅳ型胶原(CⅣ)的相关性。方法收集78例慢性丙型肝炎肝硬化患者的血清,采用日立7600全自动生化分析仪检测ALT和AST的水平,电化学发光法检测肝纤维化标志物(HA、LN及CⅣ)水平。结果肝硬化失代偿期患者血清肝纤维化指标和ALT、AST、GGT显著高于肝硬化代偿期患者(P<0.01),血清肝纤维化指标与ALT、AST、GGT呈正相关关系(P<0.01)。结论血清HA、LN及CⅣ作为肝硬化分期的指标,动态监测其变化很重要。肝纤维化指标联合肝功能检测有利于临床对丙型肝炎肝硬化演变的监测和治疗。
Objective To investigate the correlation between ALT, AST and GGT markers of serum hyaluronic acid (HA), laminin (LN) and collagen Ⅳ (C Ⅳ) in patients with chronic hepatitis C cirrhosis. Methods Seventy - eight patients with cirrhosis of chronic hepatitis C were collected. Serum levels of ALT and AST were detected by Hitachi 7600 automatic biochemistry analyzer. The levels of liver fibrosis markers HA, LN and C Ⅳ were detected by electrochemiluminescence. Results Serum levels of hepatic fibrosis and ALT, AST and GGT in patients with decompensated cirrhosis were significantly higher than those in compensated patients with cirrhosis (P <0.01). There was a positive correlation between serum markers of hepatic fibrosis and ALT, AST and GGT (P <0.01). Conclusion Serum HA, LN and CⅣ as indicators of liver cirrhosis staging, dynamic monitoring of its changes is very important. Liver fibrosis indicators combined with liver function test is conducive to clinical monitoring and treatment of hepatitis C cirrhosis.