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酸吸入性肺炎(PAAS,Mendelson氏综合征)是众所周知和令人担心的产科麻醉合并症,首先由Mendelson描述。其特征为支气管痉挛,继而发生进行性呼吸困难伴肺血分流,全身肌张力过低和肺水肿。吸入常发生在麻醉诱导期。临床研究和动物试验表明当吸入量超过25ml,pH2.5时即可有发生本症的危险。本文研究目的是对剖腹产病人麻醉前常规使用甲氰咪胍是否可行及其效果进行分析。文章对41例剖腹产病人进行前瞻性双盲实验,两例因无注射时间而除外。其余39例中20例肌肉注射甲氰咪胍400mg(100mg/ml),19例作为对照组肌肉注射0.9%NaCl4ml。用胎心产力描记作监
Acid aspiration pneumonia (PAAS, Mendelson’s syndrome) is a well known and disturbing complication of obstetric anesthesia, first described by Mendelson. It is characterized by bronchospasm followed by progressive dyspnea with pulmonary shunts, generalized hypotonia and pulmonary edema. Inhalation often occurs during induction of anesthesia. Clinical studies and animal tests show that when the amount of inhalation more than 25ml, pH2.5 can have the risk of the disease. The purpose of this study is to analyze the feasibility and effectiveness of routine use of cimetidine before caesarean section. In the article, 41 cases of caesarean section were prospectively double-blind, except for two cases with no injection time. In the remaining 39 cases, 20 cases were intramuscularly injected with cimetidine 400 mg (100 mg / ml) and 19 cases were intramuscular 0.9 ml NaCl4 ml as control group. With fetal heart rate tracer for supervision