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作者在非洲和拉丁美洲用硫胺嗪(Thiocarbamazine)作为杀丝虫剂进行了临床试验。1988年5月,在马里选择皮肤刮检微丝蚴阳性的成人盘尾丝虫病患者作试验对象,住院治疗。治疗当天和以后的60天内定期检查,计数每克皮内的微丝蚴数,同时用加藤法粪检曼氏血吸虫卵和尿检埃及血吸虫卵数,至第60天作直肠粘膜活检和尿检虫卵以评价药物的疗效。患者于前一天晚上顿服硫胺嗪20mg/kg后,排出曼氏血吸虫卵>733个/g的患者虫卵明显减少,至第60天粪检虫卵减少率达92～100％,直肠活检未见黑卵或仅见钙化卵。治前虫卵较少的19例中,11例复检证明治愈,未治愈者虫卵也减少93.4％。
The authors conducted clinical trials with Thiocarbamazine as a nematicide in Africa and Latin America. May 1988, in Mali skin scraping test selected microfilaria positive adult onchocerciasis test subjects, hospitalized. On the day of treatment and within 60 days after the regular check, count the number of microfilariae per gram of skin, while using Kato method for the detection of Schistosoma mansoni eggs and urinalysis of the number of eggs of S. japonicum to the 60th day for rectal mucosal biopsy and urinalysis eggs To evaluate the efficacy of drugs. Patients dosed with thiamazine 20 mg / kg on the night before, the number of eggs excreted> 733 / g of Schistosoma mansoni was significantly reduced, and the rate of fecal drop was 92-100% by the 60th day. The biopsy No black eggs or calcified eggs only. Of the 19 patients with fewer pre-treatment eggs, 11 were re-certified to be cured and 93.4% of those who did not heal.