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鉴于增大膳食的多不饱和脂肪酸与饱和脂肪酸的比值(P/s),可使血清胆固醇及冠心病(CHD)发病率降低,癌症的发病率升高,使人们对CHD和癌症这种相反的发病关系发生浓厚兴趣。一些流行病学证据显示:高胆固醇血是CHD的预兆,但低胆固醇水平却是癌的先兆。亦有提出,抵御CHD的保护因子高密度脂蛋白胆固醇(HDL-C)水平升高,可使癌的发病危险随之增高。许多实验表明安妥明有降血清胆固醇和CHD危险的作用,但治疗期间癌症的死亡人数亦大大增加,且伴有HDL-c水平升高。该作用模型可概括为:低总胆固醇/高
Given the dietary ratio of polyunsaturated fatty acids to saturated fatty acids (P / s), the incidence of serum cholesterol and coronary heart disease (CHD) is reduced and the incidence of cancer is elevated, giving rise to the opposite of CHD and cancer The incidence of a strong interest occurred. Some epidemiological evidence suggests that hypercholesterolemia is a precursor to CHD, but low cholesterol levels are a precursor to cancer. It has also been proposed to resist the CHD protective factor high-density lipoprotein cholesterol (HDL-C) levels, can increase the risk of cancer. Numerous experiments have shown that clofibrate has a risk of lowering serum cholesterol and CHD, but the number of cancer deaths during treatment is also greatly increased, accompanied by an increase in HDL-c levels. This model of action can be summarized as: low total cholesterol / high