A high-beam-quality diode-pumped neodymium-doped yttrium aluminum garnet (Nd:YAG) active mirror laser amplifier was demonstrated. The size of the Nd:YAG crystal was 48 mm × 42 mm × 11 mm with 0.6 at.% Nd doped. When the pump energy was 26.8 J and the input energy was 0.3 J, the output pulse energy reached 5.4 J, and the pulse width of 11.3 ns at a 5 Hz repetition rate was obtained for the two gain modules in three-pass amplification, with corresponding optical-to-optical efficiency of 21.2%. The beam quality was measured as Mx2=2.48 and My2=2.43 in horizontal and vertical directions, respectively.