以3,4-二羟基肉桂酸为介质的多壁碳纳米管糊电极用于检测药物和尿液样品中的谷胱甘肽(英文)

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A sensitive and selective electrochemical sensor for the determination of glutathione(GSH) was developed using a modified multiwall carbon nanotube paste electrode with 3,4 dihydroxy cinnamic acid as a mediator.This modified electrode showed very high electrocatalytic activity for the anodic oxidation of GSH.Under the optimized conditions,the electrocatalytic peak current showed a linear relationship with GSH concentration in the range of 0.5-400.0 μmol/L with a detection limit of 0.1 μmol/L GSH.The relative standard deviations for seven successive assays of 5.0 and 25.0 μmol/L GSH were 2.2% and 2.7%,respectively.The modified electrode was used for the determination of GSH compounds in real urine samples. A sensitive and selective electrochemical sensor for the determination of glutathione (GSH) was developed using a modified multiwall carbon nanotube paste electrode with 3,4 dihydroxy cinnamic acid as a mediator. This modified electrode showed very high electrocatalytic activity for the anodic oxidation of GSH. Under the optimized conditions, the electrocatalytic peak current showed a linear relationship with GSH concentration in the range of 0.5-400.0 μmol / L with a detection limit of 0.1 μmol / L GSH. The relative standard deviations for seven successive assays of 5.0 and 25.0 μmol / L GSH were 2.2% and 2.7% respectively. The modified electrode was used for the determination of GSH compounds in real urine samples.
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