Mattocks.A.R提出农吉利甲素(Monocrotin)所致肝中毒,系在肝内转化成吡咯衍生物后所引起。根据吡咯衍生物形成的原理,我们参照Mattocks方法半合成农甲吡咯衍生物,经给少量晚期肿瘤病人涂擦及局部注射,结果证明此衍生物有一定的抗癌效果。为便于临床推广,我们选用了常用抗肿瘤药更生霉素,环磷酰胺与农甲吡咯衍生物同时进行对比观察,为临床应用提供参考依据。 Mattocks, A.R, argues that monocrotin-induced hepatotoxicity is caused after intrahepatic conversion to pyrrole derivatives. According to the principle of the formation of pyrrole derivatives, we refer to the Mattocks method to semi-synthesize azapyrrole derivatives. After being given a small amount of advanced tumor patients and local injection, the results show that the derivatives have some anti-cancer effects. In order to facilitate clinical promotion, we use commonly used anti-cancer drug dactinomycin, cyclophosphamide and pesticide azole derivatives were observed at the same time, provide a reference for clinical application.