用反向间接血凝方法检测感染100条日本血吸虫尾蚴家兔血清中循环抗原的消长规律。其血凝滴度的几何均数在感染后2～4周时逐渐上升,5～6周达高峰,以后不再升高,波动在一定水平。当感染家兔循环抗原被检测阳性后,用硝唑咪或吡喹酮治疗。疗程结束后2周,大部分被检血清转阴。有5只观察至剖杀前未见转阴,其中2只剖杀时分别冲出雄虫2,1条,另有2只兔虽未检获成虫,但肝脏呈明显纤维化病变,与阴转的兔肝截然不同。从动物实验结果看来,本方法有希望成为疗效考核的工具。但对轻感染度动物,其阳性检出率和阳性滴度均不够理想。 Reverse circulating hemagglutination method was used to detect the growth and decline of circulating antigens in 100 rabbits infected with Schistosoma japonicum cercariae. The geometric mean titers of hemagglutination gradually increased from 2 to 4 weeks after infection and peaked from 5 to 6 weeks, and then no longer increased, fluctuating at a certain level. When infected rabbits circulating antigen was tested positive, with nitazoxan or praziquantel treatment. Two weeks after the end of treatment, most of the seizures were turned negative. There were 5 observed before the kill did not turn negative, of which 2 were killed when the male 2,1 punch, while the other two rabbits did not seize adults, but the liver showed significant fibrosis, and the negative turn Rabbit liver completely different. It seems from the animal experiment results, the method has the hope to become a tool for assessment of efficacy. However, for lightly infected animals, the positive detection rate and positive titer were not satisfactory.