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作者对严重慢性哮喘病人就家庭喷雾吸入大剂量间羟舒喘宁后,对肺功能和症状的影响进行了研究,评价了家庭喷雾治疗4周前后的支气管扩张反应并对能否发生耐药性的问题作了观察。研究对象为男14,女10,年龄在12～71岁的严重慢性哮喘患者,都使用加压气雾疗法吸入β-兴奋剂(平均每日喷11次)和定期吸入皮质类固醇。其中19人长期接受强的松治疗(平均剂量16mg/日)。研究方法为开放式,不设安慰剂组。哮喘稳定后,作者在继续使用通常药物4周和继之早晚各使用5mg的气雾间羟舒喘宁4周病人之间进行比较。
The authors studied the effects of inhaled high-dose oxybutanenol in household spray on lung function and symptoms in patients with severe chronic asthma and evaluated the bronchodilator response 4 weeks before home spray therapy and whether drug resistance The issue was observed. Patients 14, 10, and 12 to 71 years of age with severe chronic asthma were treated with pressurized aerosol inhalation of beta-agonists (average 11 times a day) and regular inhaled corticosteroids. Of these, 19 received long-term prednisone treatment (mean dose of 16 mg / day). The study was open-ended, with no placebo. After stabilization of asthma, the authors compared the 4 weeks of usual drug use to 4 weeks of usual drug and 4 weeks of use of aerosol salbutamol 5 mg each morning and evening.