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目的探讨WLGY-801肝病治疗仪联合左旋咪唑涂布剂治疗慢性乙型肝炎的临床疗效。方法选择84例慢性乙型肝炎患者,随机分成治疗组42例和对照组42例,两组患者均采用常规复方甘草酸苷保肝治疗,治疗组加用肝病治疗仪联合左旋咪唑涂布剂穴位导入治疗,一日1次,30d为1疗程,共3个疗程,对照组为干扰素组。治疗仪组和对照组均在常规保肝降酶治疗的基础上用药;比较临床症状、ALT、AST、HBVM的变化。结果治疗组在综合疗效、临床症状、体征、肝功能改善、在e抗原(HBeAg)转阴、e抗体(HbeAb)转阳、HBV-DNA滴度下降方面与对照组比较有统计学意义(P<0.01或P<0.05)。结论 WLGY-801型电脑肝病治疗仪联合药物治疗慢性乙型肝炎可以改善临床症状,e抗原(HBeAg)转阴、e抗体(HbeAb)转阳、HBV-DNA滴度下降方面提高疗效,缩短病程,并有一定的调节人体免疫功能,抑制HBV-DNA复制。
Objective To investigate the clinical efficacy of WLGY-801 liver disease treatment instrument combined with levamisole coating in the treatment of chronic hepatitis B patients. Methods Eighty-four patients with chronic hepatitis B were randomly divided into treatment group (n = 42) and control group (n = 42). Both groups were treated with conventional compound glycyrrhizin and liver preservation treatment. Patients in treatment group were treated with combination therapy of liver disease and levamisole Imported treatment, once a day, 30d for a course of treatment, a total of three courses, the control group for the interferon group. The treatment instrument group and the control group were treated on the basis of regular liver protection and enzyme-lowering treatment. The changes of clinical symptoms, ALT, AST and HBVM were compared. Results Compared with the control group, the treatment group had statistically significant (P> 0.05) in the aspects of comprehensive curative effect, clinical symptoms, signs and liver function, and decreased in e antigen (HBeAg), HbeAb positive and HBV- <0.01 or P <0.05). Conclusion The treatment of chronic hepatitis B with WLGY-801 computerized liver disease treatment instrument can improve the clinical symptoms, improve the curative effect and reduce the course of disease with e antigen (HBeAg) negative, HbeAb positive and HBV-DNA titer decrease, And a certain regulation of human immune function, inhibition of HBV-DNA replication.