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骨是一种动态更新的组织,它不断进行骨吸收(bone resorption)与骨形成(bone formation)的平衡,这个过程称之为骨重建(bone remodeling).核因子κB受体活化因子配体(receptor activator of nuclear factorκB ligand,RANKL)是骨吸收和骨形成耦联的关键,具有诱导破骨细胞(osteoclast,OC)生成、活化,抑制破骨细胞凋亡的作用.RANKL最初发现于活化的T细胞,但骨重建过程中RANKL主要来源于骨细胞、成骨细胞和骨髓基质细胞.RANKL/核因子κB受体活化因子(receptor activator of nuclear factorκB,RANK)/骨保护素(osteoprotegerin,OPG)信号通路在成骨细胞调控破骨细胞生成的过程中起着重要的调节作用,是维持骨重建平衡的关键.本文就RANKL及其在骨中的分子作用机制作一综述.
Bone is a dynamically renewed tissue that continually balances bone resorption with bone formation, a process known as bone remodeling. Nuclear factor κB receptor activator ligands ( receptor activator of nuclear factor κB ligand (RANKL) is the key of bone resorption and bone formation and induces osteoclast (OC) production, activation and inhibition of osteoclast apoptosis.RANKL was initially found in activated T However, RANKL is mainly derived from osteoblasts, osteoblasts and bone marrow stromal cells during bone remodeling.RANKL / RANK / OPG signal Pathway plays an important regulatory role in osteoblast regulation of osteoclastogenesis and is the key to maintain the balance of bone remodeling.In this paper, the molecular mechanism of RANKL and its function in bone were reviewed.