目的　观察自体外周血干细胞移植治疗糖尿病足的临床疗效及相关影响因素。方法　自 2 0 0 3- 112 0 0 4 - 0 7解放军第 4 6 3医院对 2 6例自愿接受自体外周血干细胞移植的糖尿病足患者进行外周血干细胞动员 ,给予rhG -CSF每天 4 5 0 6 0 0 μg ,皮下注射 ,第 6天用COBE 6 1血细胞分离机单采干细胞 ,总量 82 14 8mL。将干细胞悬液按 3cm×3cm距离进行缺血肢体移植术 ,移植后观察各项指标综合评估。结果　移植后 314d 2 3例患者疼痛明显缓解 ,2 7d2 4例患肢冷感有不同程度的改善 ,4 12周 4例溃疡明显好转 ,踝压指数 (ABI) 6例患者改善。 2例DSA下肢动脉造影结果显示新侧支血管形成明显增加。未出现并发症和不良反应。结论　自体外周血干细胞移植治疗糖尿病足是一种简便、安全、有效的治疗方法 Objective To observe the clinical efficacy and related factors of autologous peripheral blood stem cell transplantation in the treatment of diabetic foot. Methods Peripheral blood stem cell mobilization was performed in 266 PLA volunteers who received autologous peripheral blood stem cell transplantation from the Department of Hospital, 3rd Hospital of PLA, Chinese PLA from March 2000 to March 2006. 0 μg, injected subcutaneously, on day 6, stem cells were collected using a COBE 6 1 blood cell separator totaling 82,148 mL. The stem cell suspension by 3cm × 3cm distance ischemic limb transplantation, after the observation of various indicators comprehensive evaluation. Results Three days after transplantation, the pain relief was relieved in 3 of 3 patients, and the cold sensation in 4 limbs at 27 days was improved to some degree. In 4 weeks, the ulcer in 4 cases improved markedly, and the ankle pressure index (ABI) in 6 cases improved. 2 cases of DSA arterial angiography showed a significant increase in the formation of new collateral vessels. No complications and adverse reactions occurred. Conclusion Autologous peripheral blood stem cell transplantation for the treatment of diabetic foot is a simple, safe and effective treatment