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[目的]通过监测重症监护室金黄色葡萄球菌感染及耐药性变化，探讨重症监护室综合性干预对控制医院感染的作用。[方法]采用回顾性分析的方法，对某医院2011年和2012年重症监护室采取综合性干预措施前后，患者金黄色葡萄球菌的分离结果进行对比性分析。[结果]两年间金黄色葡萄球菌的分离率无明显差异（P＞0．05），但耐甲氧西林金黄色葡萄球菌构成比明显下降，差异有统计学意义（P＜0．05）。金黄色葡萄球菌对苯唑西林、环丙沙星和左氧氟沙星的耐药率明显下降（P＜0．05）。两年间重症监护室金黄色葡萄球菌对万古霉素、替考拉宁、利奈唑胺、呋喃妥因和喹奴普汀-达福普汀敏感率最高，均达100．00％。[结论]通过综合性干预，重症监护室金黄色葡萄球菌感染情况得到改善，耐药率总体有所下降。“,”Objective] To discuss comprehensive intervention effect on the control of hospital in-fections in the intensive care unit ( ICU ) of a hospital by monitoring Staphylococcus aureus infections and their drug resistance . [ Methods] Comparative analysis was done retrospectively in separation results of Staphylococcus aureus between 2011 and 2012 in ICU patients of a hospital . [ Results] Between 2011 and 2012, there was no obvious difference found in relevance ratio of Staphylococcus aureus(P>0.05), but that of methicillin resistant Staphylococcus aureus was on the decline significantly (P<0.05).The drug re-sistance rates of Staphylococcus aureus to oxacillin, ciprofloxacin, levofloxacin were on the decline signifi-cantly(P <0.05).The drug susceptibility rates of Staphylococcus aureus to vancomycin, teicoplanin, linezolid , nitrofurantoin and primaquine slave tianeptine/dafoe tianeptine were the highest , reaching up to 100.00%. [ Conclusion] By comprehensive intervention , Staphylococcus aureus infections in ICU have been improved and drug resistance rates on the decline as a whole .