肺黏液纤毛清除功能缺陷,可导致黏液栓形成并削弱微生物和微粒的清除。在呼吸道合胞病毒感染婴儿和哮喘患者中,这些缺陷而造成纤毛上皮细胞受损及黏液过度产生。本研究用培养的人呼吸道上皮细胞研究纤毛受损和修复机制。经白细胞介素-13治疗的细胞纤毛细胞受损率为65%～90%,且纤毛形成过程中必要的foxj1 Pulmonary mucociliary clearance defects, can lead to mucus plug formation and weaken the clearance of microorganisms and particles. These defects result in impaired ciliated epithelial cells and excessive production of mucus in infants and asthmatics infected with RSV. In this study, cultured human respiratory epithelial cells were used to study the mechanism of cilia damage and repair. Interleukin-13 treatment of cell ciliated cells damage rate of 65% to 90%, and the necessary ciliary formation during foxj1