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目的探讨紫杉醇(TXT)联合三维适形放疗(3D-CRT)治疗局部晚期(Ⅲ期)非小细胞肺癌的疗效。方法选取2013年1月至2016年1月间武汉大学人民医院收治的160例非小细胞肺癌ⅢA~ⅢB期患者,采用随机数字表法分为观察组和对照组,每组80例。观察组患者予以TXT联合3D-CRT治疗,对照组患者予以紫杉醇联合卡铂(TP方案)化疗,治疗3个疗程后进行疗效评价,比较两组患者的疗效和不良反应发生情况。结果观察组患者部分缓解率(PR)高于对照组患者,两组比较差异有统计学意义(P<0.05),疾病进展率(PD)低于对照组患者,两组比较差异有统计学意义(P<0.01)。对照组患者胃肠道反应、骨髓抑制和肝功能损害发生率均高于观察组患者,两组比较差异均有统计学意义(均P<0.05)。结论紫杉醇联合三维适形放疗治疗局部晚期非小细胞肺癌具有较好的临床效果,提高了药物的抗肿瘤作用,降低了不良反应的发生。
Objective To investigate the efficacy of paclitaxel (TXT) and three-dimensional conformal radiotherapy (3D-CRT) in the treatment of locally advanced (stage Ⅲ) non-small cell lung cancer. Methods A total of 160 non-small cell lung cancer patients with stage ⅢA-ⅢB admitted to Wuhan University People’s Hospital from January 2013 to January 2016 were randomly divided into observation group (n = 80) and control group (n = 80). Patients in the observation group were treated with TXT combined with 3D-CRT. Patients in the control group were treated with paclitaxel combined with carboplatin (TP regimen). The curative effect was evaluated after 3 courses of treatment. The curative effect and adverse reactions of the two groups were compared. Results The partial response rate (PR) in the observation group was significantly higher than that in the control group, the difference was statistically significant (P <0.05), the disease progression rate (PD) was lower than the control group, the difference was statistically significant (P <0.01). The incidence of gastrointestinal reactions, bone marrow suppression and hepatic dysfunction in the control group were significantly higher than those in the observation group. There was significant difference between the two groups (all P <0.05). Conclusion paclitaxel combined with three-dimensional conformal radiotherapy for the treatment of locally advanced non-small cell lung cancer has a good clinical effect, improve the anti-tumor effect of drugs and reduce the incidence of adverse reactions.